Fibroid Studies

Uterine fibroids are extremely common noncancerous tumors of the uterus present in at least 25% of premenopausal women. Fibroids may cause heavy bleeding, pelvic pain or pressure, problems with bowel or bladder function, infertility, or poor pregnancy outcomes. These health problems can have a significant impact on a woman’s life taking a social, emotional, and economic toll. Through innovative research, we investigate women’s health needs across the full spectrum of a woman’s life.

Until recently, most clinical trials included only men, missing the differences in health risks and outcomes for women. We’re working to improve prevention, treatment and care by understanding these differences among diverse groups of women.

 

What is COMPARE-UF?

COMPARE-UF is a nationwide study to help women and doctors better understand the effects of different treatments options for fibroids including symptom relief, fertility and pregnancy, and the need for additional fibroid treatment.

Each participant will make treatment decisions with her personal doctor, and then share information about her current and past experiences with her fibroids, including how fibroids have impacted her quality of her life. You may qualify for the study if:

  • You are a woman, 18 years or older
  • You are premenopausal
  • You have symptomatic uterine fibroids
  • You are planning treatment for your uterine fibroids

How can I learn more about COMPARE-UF?

If you are interested in COMPARE-UF, please contact our research coordinators at 415-297-3114 or fibroids@ucsf.edu.

What is PLUM?

The PLUM study (Pilot of Letrozole to treat Uterine Leiomyoma) is a study of a medication called letrozole to treat uterine fibroids. You may be eligible for the study if you are:

  • Are a premenopausal woman
  • Have fibroids that cause significant symptoms

What is letrozole?

Letrozole is a pill that is used for many different purposes in women’s health including treatment of infertility, endometriosis, and uterine fibroids. Letrozole is a non-hormonal medication called an aromatase inhibitor. Letrozole works by shrinking down fibroid size to improve fibroid-related symptoms. Although letrozole is used to treat some gynecologic conditions, it is approved by the FDA for a different purpose: to treat postmenopausal women with hormone sensitive breast cancer. Therefore, in this study, the use of letrozole in considered investigational (not FDA approved).

Why is this study being done? 

Although some gynecologists use letrozole in their clinical practice to treat women with fibroids, there have been very few studies to evaluate the effectiveness of treatment. This goal of this study is to understand how the use of letrozole impacts fibroid-related symptoms and fibroid size.

Can my fibroids be treated with letrozole?

Women who are having symptoms related to fibroids such as heavy bleeding, pelvic pressure, or urinary frequency may be eligible for treatment with letrozole. At your initial visit, you and the gynecologist will discuss your symptoms and your treatment goals, and review the position and size of your fibroids with radiology imaging (pelvic ultrasound and/or MRI). We will also review with you other possible treatment options for your fibroid-related symptoms including nonsurgical and surgical options.

How can I make an appointment to discuss enrolling in the PLUM study of letrozole?

If you are interested in letrozole treatment for fibroids, please contact our research coordinators at 415-297-3114 or fibroids@ucsf.edu.

What is the ULTRA Study?

ULTRA is a study of a new, FDA approved fibroid treatment called radiofrequency ablation (Acessa™) . This procedure uses heat to destroy fibroid tissue during a laparoscopic surgery. Women return home on the same day as the procedure and are back to their normal activities in 5-9 days. The goal of the study is to evaluate how fibroid symptoms change over time after radiofrequency ablation (Acessa™) . If you participate in the ULTRA study, you will receive radiofrequency ablation (Acessa™) and complete questionnaires about your fibroid symptoms and reproductive health. You may be eligible to participate in the study if you:

  • Are at least 21 years of age
  • Have uterine fibroids that cause heavy bleeding, pelvic pressure or discomfort, urinary or bowel symptoms, or dyspareunia (painful sexual intercourse)
  • Are able to undergo laparoscopic surgery

You can read more about the ULTRA study at http://clinicaltrials.gov/show/NCT01840124 

If you are interested in participating in ULTRA, please contact the study coordinator at 415-297-3114 or by e-mail: fibroids@ucsf.edu. Or go to the study website at http://fibroids.ucsf.edu/