Alka Kanaya, MD

Professor In Residence

I have focused my clinical research in the field of type 2 diabetes and obesity and have developed a three-pronged research program that is unified under this theme. The first arm consists of using existing cohort studies to test novel biomarkers that predict diabetes and cardiovascular disease. The second arm is to create a South Asian cohort to study these risk factors in a very high risk group. The final arm is to test behavioral interventions to prevent the onset of diabetes.

The first arm of my research program focuses on understanding novel biomarkers secreted from adipose tissue that may be responsible for the metabolic sequelae associated with obesity. I assayed adiponectin from over 3,000 frozen serum specimens from a longitudinal cohort and have performed a series of analyses finding that abdominal visceral adiposity when directly measured by CT scan is significantly associated with type 2 diabetes and adipocytokines, proteins produced by adipose tissue, explain this association. We have found strong links between visceral adiposity and adipocytokines predicting risk of diabetes, cardiovascular disease, and mortality.

The second arm of my research program has been to establish a population-based cohort of South Asian adults. South Asians have very high prevalence of diabetes and cardiovascular disease and have been poorly studied. With a K23 grant from the NHLBI, I recruited 150 South Asians in a pilot cohort study which was modelled on the existing Multi-Ethnic Study of Atherosclerosis (MESA). In this project, called the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA study), we have examined the relationship between metabolic factors and atherosclerosis measured by carotid ultrasound and coronary artery calcium. We found that compared to the four ethnic groups in MESA (Whites, African Americans, Latinos, and Chinese Americans), South Asians had higher diabetes prevalence[58] despite having favorable lifestyle risk factors. I received additional funding to study endothelial function in this cohort through the American Heart Association and we finished our second clinical examination visits in January 2010. I have been awarded a new R01 grant to expand and prospectively follow this South Asian cohort at two clinical sites to chart the natural history of diabetes and atherosclerosis and test novel risk factors. I have submitted another R01 grant to create a new multi-dimensional tool to measure cultural beliefs and adaptations among South Asian Americans. This project will involve both qualitative and quantitative methods and will help us understand cultural risk factors for cardiovascular disease in this high risk ethnic group.

The third arm includes testing behavioral interventions to prevent diabetes in high risk individuals. We have conducted a translational randomized controlled trial testing the effectiveness of a lifestyle intervention provided by the Berkeley Public Health Department to decrease diabetes risk factors in low-income ethnic minority groups. I have also completed a pilot randomized controlled trial to test the feasibility of Restorative yoga in overweight adults with the metabolic syndrome. We found that Restorative yoga was feasible with trends toward improvements in waist circumference and blood pressure in the yoga group compared to the control group. I have been awarded an R01 grant to test this intervention vs. a stretching control group in a multicenter randomized controlled trial called PRYSMS which is currently underway.

The three arms of my research agenda complement each other and provide fertile ground to develop and test new hypotheses with the ultimate goal of better caring for patients at high risk of diabetes and cardiovascular disease.

Publications: 

Type 2 Diabetes After Gestational Diabetes Mellitus in South Asian Women in the United States.

Diabetes/metabolism research and reviews

Gadgil MD, Oza-Frank R, Kandula NR, Kanaya AM

Psychosocial Factors Associated with Subclinical Atherosclerosis in South Asians: The MASALA Study.

Journal of immigrant and minority health

Shah BM, Shah S, Kandula NR, Gadgil MD, Kanaya AM

Ectopic Fat Depots and Coronary Artery Calcium in South Asians Compared With Other Racial/Ethnic Groups.

Journal of the American Heart Association

Garg SK, Lin F, Kandula N, Ding J, Carr J, Allison M, Liu K, Herrington D, Vaidya D, Vittinghoff E, Kanaya AM

Hispanics/Latinos With Type 2 Diabetes Have Functional and Symptomatic Pulmonary Impairment Mirroring Kidney Microangiopathy: Findings From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Diabetes care

Klein OL, Aviles-Santa L, Cai J, Collard HR, Kanaya AM, Kaplan RC, Kinney GL, Mendes E, Smith L, Talavera G, Wu D, Daviglus M

Clinical anthropometrics and body composition from 3D whole-body surface scans.

European journal of clinical nutrition

Ng BK, Hinton BJ, Fan B, Kanaya AM, Shepherd JA

Circulating cellular adhesion molecules and risk of diabetes: the Multi-Ethnic Study of Atherosclerosis (MESA).

Diabetic medicine : a journal of the British Diabetic Association

Pankow JS, Decker PA, Berardi C, Hanson NQ, Sale M, Tang W, Kanaya AM, Larson NB, Tsai MY, Wassel CL, Bielinski SJ

Association of Muscle Mass, Area, and Strength With Incident Diabetes in Older Adults: The Health ABC Study.

The Journal of clinical endocrinology and metabolism

Larsen BA, Wassel CL, Kritchevsky SB, Strotmeyer ES, Criqui MH, Kanaya AM, Fried LF, Schwartz AV, Harris TB, Ix JH

Normal-Weight Central Obesity and Mortality Risk in Older Adults With Coronary Artery Disease.

Mayo Clinic proceedings

Sharma S, Batsis JA, Coutinho T, Somers VK, Hodge DO, Carter RE, Sochor O, Kragelund C, Kanaya AM, Zeller M, Park JS, Køber L, Torp-Pedersen C, Lopez-Jimenez F

Less favorable body composition and adipokines in South Asians compared with other US ethnic groups: results from the MASALA and MESA studies.

International journal of obesity (2005)

Shah AD, Kandula NR, Lin F, Allison MA, Carr J, Herrington D, Liu K, Kanaya AM

Circulating micrornas associated with glycemic impairment and progression in Asian Indians.

Biomarker research

Flowers E, Gadgil M, Aouizerat BE, Kanaya AM

Endogenous Sex Steroid Hormones, Lipid Subfractions, and Ectopic Adiposity in Asian Indians.

Metabolic syndrome and related disorders

Kim C, Kong S, Krauss RM, Stanczyk FZ, Reddy ST, Needham BL, Kanaya AM

Body Mass Index Trajectories in Relation to Change in Lean Mass and Physical Function: The Health, Aging and Body Composition Study.

Journal of the American Geriatrics Society

Reinders I, Murphy RA, Martin KR, Brouwer IA, Visser M, White DK, Newman AB, Houston DK, Kanaya AM, Nagin DS, Harris TB

Does type 2 diabetes increase rate of cognitive decline in older Mexican Americans?

Alzheimer disease and associated disorders

Mayeda ER, Haan MN, Yaffe K, Kanaya AM, Neuhaus J

Dietary intakes among South Asian adults differ by length of residence in the USA.

Public health nutrition

Talegawkar SA, Kandula NR, Gadgil MD, Desai D, Kanaya AM

Dietary patterns are associated with metabolic risk factors in South Asians living in the United States.

The Journal of nutrition

Gadgil MD, Anderson CA, Kandula NR, Kanaya AM

Comparing Type 2 Diabetes, Prediabetes, and Their Associated Risk Factors in Asian Indians in India and in the U.S.: The CARRS and MASALA Studies.

Diabetes care

Gujral UP, Narayan KM, Pradeepa RG, Deepa M, Ali MK, Anjana RM, Kandula NR, Mohan V, Kanaya AM

Optimum BMI cut points to screen asian americans for type 2 diabetes.

Diabetes care

Araneta MR, Kanaya AM, Hsu WC, Chang HK, Grandinetti A, Boyko EJ, Hayashi T, Kahn SE, Leonetti DL, McNeely MJ, Onishi Y, Sato KK, Fujimoto WY

BMI cut points to identify at-risk Asian Americans for type 2 diabetes screening.

Diabetes care

Hsu WC, Araneta MR, Kanaya AM, Chiang JL, Fujimoto W

Endogenous sex steroid hormones and glucose in a South-Asian population without diabetes: the Metabolic Syndrome and Atherosclerosis in South-Asians Living in America pilot study.

Diabetic medicine : a journal of the British Diabetic Association

Needham BL, Kim C, Mukherjee B, Bagchi P, Stanczyk FZ, Kanaya AM

The association between body composition and cystatin C in South Asians: results from the MASALA study.

Obesity research & clinical practice

Shah AD, Schmidt H, Sen S, Shlipak MG, Kanaya AM

Long-term prevalence and predictors of urinary incontinence among women in the Diabetes Prevention Program Outcomes Study.

International journal of urology : official journal of the Japanese Urological Association

Phelan S, Kanaya AM, Ma Y, Vittinghoff E, Barrett-Connor E, Wing R, Kusek JW, Orchard TJ, Crandall JP, Montez MG, Brown JS

Vitamin D insufficiency and abnormal hemoglobin a1c in black and white older persons.

The journals of gerontology. Series A, Biological sciences and medical sciences

Kositsawat J, Kuchel GA, Tooze JA, Houston DK, Cauley JA, Kritchevsky SB, Strotmeyer ES, Kanaya AM, Harris TB, Johnson KC, Barry LC

Diabetes and associated complications in the South Asian population.

Current cardiology reports

Shah A, Kanaya AM

Using appropriate body mass index cut points for overweight and obesity among Asian Americans.

Preventive medicine

Jih J, Mukherjea A, Vittinghoff E, Nguyen TT, Tsoh JY, Fukuoka Y, Bender MS, Tseng W, Kanaya AM

Understanding the high prevalence of diabetes in U.S. south Asians compared with four racial/ethnic groups: the MASALA and MESA studies.

Diabetes care

Kanaya AM, Herrington D, Vittinghoff E, Ewing SK, Liu K, Blaha MJ, Dave SS, Qureshi F, Kandula NR

Comparing coronary artery calcium among U.S. South Asians with four racial/ethnic groups: the MASALA and MESA studies.

Atherosclerosis

Kanaya AM, Kandula NR, Ewing SK, Herrington D, Liu K, Blaha MJ, Srivastava S, Dave SS, Budoff MJ

Incident heart failure in relation to vascular disease: insights from the Health, Aging, and Body Composition Study.

European journal of heart failure

Khan H, Kalogeropoulos AP, Zannad F, Marti CN, Wilson PW, Georgiopoulou VV, Kanaya AM, Newman AB, Schelbert E, Harris TB, Kritchevsky S, Yancy C, Gheorghiade M, Fonarow GC, Butler J

Changes in procoagulants track longitudinally with insulin resistance: findings from the coronary artery risk development in young adults (CARDIA) study.

Diabetic medicine : a journal of the British Diabetic Association

Klein OL, Okwuosa T, Chan C, Schreiner P, Kanaya AM, Liu K, Green D

Restorative yoga and metabolic risk factors: the Practicing Restorative Yoga vs. Stretching for the Metabolic Syndrome (PRYSMS) randomized trial.

Journal of diabetes and its complications

Kanaya AM, Araneta MR, Pawlowsky SB, Barrett-Connor E, Grady D, Vittinghoff E, Schembri M, Chang A, Carrion-Petersen ML, Coggins T, Tanori D, Armas JM, Cole RJ

Mediators of Atherosclerosis in South Asians Living in America (MASALA) study: objectives, methods, and cohort description.

Clinical cardiology

Kanaya AM, Kandula N, Herrington D, Budoff MJ, Hulley S, Vittinghoff E, Liu K

Elevated HbA1c and fasting plasma glucose in predicting diabetes incidence among older adults: are two better than one?

Diabetes care

Lipska KJ, Inzucchi SE, Van Ness PH, Gill TM, Kanaya A, Strotmeyer ES, Koster A, Johnson KC, Goodpaster BH, Harris T, De Rekeneire N

Incidence of type 2 diabetes by place of birth in the Multi-Ethnic Study of Atherosclerosis (MESA).

Journal of immigrant and minority health / Center for Minority Public Health

Oza-Frank R, Chan C, Liu K, Burke G, Kanaya AM

Diabetes, depressive symptoms, and inflammation in older adults: results from the Health, Aging, and Body Composition Study.

Journal of psychosomatic research

Doyle TA, de Groot M, Harris T, Schwartz F, Strotmeyer ES, Johnson KC, Kanaya A

Lipid peroxidation and depressed mood in community-dwelling older men and women.

PloS one

Milaneschi Y, Cesari M, Simonsick EM, Vogelzangs N, Kanaya AM, Yaffe K, Patrignani P, Metti A, Kritchevsky SB, Pahor M, Ferrucci L, Penninx BW

Glycemic associations with endothelial function and biomarkers among 5 ethnic groups: the Multi-Ethnic Study of Atherosclerosis and the Mediators of Atherosclerosis in South Asians Living in America studies.

Journal of the American Heart Association

Kanaya AM, Dobrosielski DA, Ganz P, Creasman J, Gupta R, Nelacanti V, Vogel-Claussen J, Herrington D

Combining body mass index with measures of central obesity in the assessment of mortality in subjects with coronary disease: role of "normal weight central obesity".

Journal of the American College of Cardiology

Coutinho T, Goel K, Corrêa de Sá D, Carter RE, Hodge DO, Kragelund C, Kanaya AM, Zeller M, Park JS, Kober L, Torp-Pedersen C, Cottin Y, Lorgis L, Lee SH, Kim YJ, Thomas R, Roger VL, Somers VK, Lopez-Jimenez F

A long way from home: comparing mental health measures between foreign and U.S.-born Latinos in the Multi-Ethnic Study of Atherosclerosis (MESA).

Journal of health care for the poor and underserved

Casillas A, Leng M, Liu K, Hernandez A, Shrager S, Kanaya A

Elevated rates of diabetes in Pacific Islanders and Asian subgroups: The Diabetes Study of Northern California (DISTANCE).

Diabetes care

Karter AJ, Schillinger D, Adams AS, Moffet HH, Liu J, Adler NE, Kanaya AM

Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.

Human molecular genetics

Qi Q, Menzaghi C, Smith S, Liang L, de Rekeneire N, Garcia ME, Lohman KK, Miljkovic I, Strotmeyer ES, Cummings SR, Kanaya AM, Tylavsky FA, Satterfield S, Ding J, Rimm EB, Trischitta V, Hu FB, Liu Y, Qi L

Thyroid function and prevalent and incident metabolic syndrome in older adults: the Health, Ageing and Body Composition Study.

Clinical endocrinology

Waring AC, Rodondi N, Harrison S, Kanaya AM, Simonsick EM, Miljkovic I, Satterfield S, Newman AB, Bauer DC

Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implications.

Diabetes care

Hsu WC, Boyko EJ, Fujimoto WY, Kanaya A, Karmally W, Karter A, King GL, Look M, Maskarinec G, Misra R, Tavake-Pasi F, Arakaki R

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.

PLoS genetics

Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, Beekman M, Coassin S, Lohman K, Qi L, Kanoni S, Pankow JS, Uh HW, Wu Y, Bidulescu A, Rasmussen-Torvik LJ, Greenwood CM, Ladouceur M, Grimsby J, Manning AK, Liu CT, Kooner J, Mooser VE, Vollenweider P, Kapur KA, Chambers J, Wareham NJ, Langenberg C, Frants R, Willems-Vandijk K, Oostra BA, Willems SM, Lamina C, Winkler TW, Psaty BM, Tracy RP, Brody J, Chen I, Viikari J, Kähönen M, Pramstaller PP, Evans DM, St Pourcain B, Sattar N, Wood AR, Bandinelli S, Carlson OD, Egan JM, Böhringer S, van Heemst D, Kedenko L, Kristiansson K, Nuotio ML, Loo BM, Harris T, Garcia M, Kanaya A, Haun M, Klopp N, Wichmann HE, Deloukas P, Katsareli E, Couper DJ, Duncan BB, Kloppenburg M, Adair LS, Borja JB

Metabolic Syndrome Derived from Principal Component Analysis and Incident Cardiovascular Events: The Multi Ethnic Study of Atherosclerosis (MESA) and Health, Aging, and Body Composition (Health ABC).

Cardiology research and practice

Agarwal S, Jacobs DR, Vaidya D, Sibley CT, Jorgensen NW, Rotter JI, Chen YD, Liu Y, Andrews JS, Kritchevsky S, Goodpaster B, Kanaya A, Newman AB, Simonsick EM, Herrington DM

Oxidative damage, platelet activation, and inflammation to predict mobility disability and mortality in older persons: results from the health aging and body composition study.

The journals of gerontology. Series A, Biological sciences and medical sciences

Cesari M, Kritchevsky SB, Nicklas B, Kanaya AM, Patrignani P, Tacconelli S, Tranah GJ, Tognoni G, Harris TB, Incalzi RA, Newman AB, Pahor M

Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial.

The Journal of urology

Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin AA, West DS, Brown JS

Dietary patterns, insulin sensitivity and inflammation in older adults.

European journal of clinical nutrition

Anderson AL, Harris TB, Tylavsky FA, Perry SE, Houston DK, Lee JS, Kanaya AM, Sahyoun NR

The effects of adiponectin and leptin on changes in bone mineral density.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Barbour KE, Zmuda JM, Boudreau R, Strotmeyer ES, Horwitz MJ, Evans RW, Kanaya AM, Harris TB, Cauley JA

Adipokines and the risk of fracture in older adults.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Barbour KE, Zmuda JM, Boudreau R, Strotmeyer ES, Horwitz MJ, Evans RW, Kanaya AM, Harris TB, Bauer DC, Cauley JA

An innovative multiphased strategy to recruit underserved adults into a randomized trial of a community-based diabetes risk reduction program.

The Gerontologist

Santoyo-Olsson J, Cabrera J, Freyre R, Grossman M, Alvarez N, Mathur D, Guerrero M, Delgadillo AT, Kanaya AM, Stewart AL

Central obesity and survival in subjects with coronary artery disease: a systematic review of the literature and collaborative analysis with individual subject data.

Journal of the American College of Cardiology

Coutinho T, Goel K, Corrêa de Sá D, Kragelund C, Kanaya AM, Zeller M, Park JS, Kober L, Torp-Pedersen C, Cottin Y, Lorgis L, Lee SH, Kim YJ, Thomas R, Roger VL, Somers VK, Lopez-Jimenez F

Asian Americans and obesity in California: a protective effect of biculturalism.

Journal of immigrant and minority health / Center for Minority Public Health

Wang S, Quan J, Kanaya AM, Fernandez A

Heterogeneity of diabetes outcomes among asians and pacific islanders in the US: the diabetes study of northern california (DISTANCE).

Diabetes care

Kanaya AM, Adler N, Moffet HH, Liu J, Schillinger D, Adams A, Ahmed AT, Karter AJ

Correlates of insulin resistance in older individuals with and without kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Landau M, Kurella-Tamura M, Shlipak MG, Kanaya A, Strotmeyer E, Koster A, Satterfield S, Simsonick EM, Goodpaster B, Newman AB, Fried LF

F2-isoprostanes and adiposity in older adults.

Obesity (Silver Spring, Md.)

Kanaya AM, Wassel CL, Stoddard PJ, Harris TB, Cummings SR, Kritchevsky SB, Goodpaster BH, Green C, Satterfield S, Gross MD

Plasma F2-isoprostane level and cognitive function over eight years in non-demented older adults: Findings from the Health ABC Study.

Prostaglandins, leukotrienes, and essential fatty acids

Fiocco AJ, Kanaya AM, Lindquist KM, Harris TB, Satterfield S, Simonsick EM, Kuller L, Rosano C, Yaffe K

Identifying dysglycemic states in older adults: implications of the emerging use of hemoglobin A1c.

The Journal of clinical endocrinology and metabolism

Lipska KJ, De Rekeneire N, Van Ness PH, Johnson KC, Kanaya A, Koster A, Strotmeyer ES, Goodpaster BH, Harris T, Gill TM, Inzucchi SE

Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults.

The Journal of clinical endocrinology and metabolism

Schafer AL, Vittinghoff E, Lang TF, Sellmeyer DE, Harris TB, Kanaya AM, Strotmeyer ES, Cawthon PM, Cummings SR, Tylavsky FA, Scherzinger AL, Schwartz AV

BMD reference standards among South Asians in the United States.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

Melamed A, Vittinghoff E, Sriram U, Schwartz AV, Kanaya AM

Description of an academic community partnership lifestyle program for lower income minority adults at risk for diabetes.

The Diabetes educator

Delgadillo AT, Grossman M, Santoyo-Olsson J, Gallegos-Jackson E, Kanaya AM, Stewart AL

A polymorphism near IGF1 is associated with body composition and muscle function in women from the Health, Aging, and Body Composition Study.

European journal of applied physiology

Kostek MC, Devaney JM, Gordish-Dressman H, Harris TB, Thompson PD, Clarkson PM, Angelopoulos TJ, Gordon PM, Moyna NM, Pescatello LS, Visich PS, Zoeller RF, Seip RL, Garcia M, Li R, Zmuda JM, Delmonico MJ, Kanaya A, Hoffman EP

Body fat distribution and inflammation among obese older adults with and without metabolic syndrome.

Obesity (Silver Spring, Md.)

Koster A, Stenholm S, Alley DE, Kim LJ, Simonsick EM, Kanaya AM, Visser M, Houston DK, Nicklas BJ, Tylavsky FA, Satterfield S, Goodpaster BH, Ferrucci L, Harris TB

Dietary fat and cholesterol and risk of cardiovascular disease in older adults: the Health ABC Study.

Nutrition, metabolism, and cardiovascular diseases : NMCD

Houston DK, Ding J, Lee JS, Garcia M, Kanaya AM, Tylavsky FA, Newman AB, Visser M, Kritchevsky SB

Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study.

Diabetes/metabolism research and reviews

Njajou OT, Kanaya AM, Holvoet P, Connelly S, Strotmeyer ES, Harris TB, Cummings SR, Hsueh WC

Joint association of obesity and metabolic syndrome with incident mobility limitation in older men and women--results from the Health, Aging, and Body Composition Study.

The journals of gerontology. Series A, Biological sciences and medical sciences

Stenholm S, Koster A, Alley DE, Houston DK, Kanaya A, Lee JS, Newman AB, Satterfield S, Simonsick EM, Visser M, Harris TB, Ferrucci L

Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition Study.

Journal of the American Geriatrics Society

Hu D, Pawlikowska L, Kanaya A, Hsueh WC, Colbert L, Newman AB, Satterfield S, Rosen C, Cummings SR, Harris TB, Ziv E

Prevalence and risk factors for urinary incontinence in overweight and obese diabetic women: action for health in diabetes (look ahead) study.

Diabetes care

Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, Dilillo V, Gorin AA, West DS, Brown JS

Serum resistin concentrations and risk of new onset heart failure in older persons: the health, aging, and body composition (Health ABC) study.

Arteriosclerosis, thrombosis, and vascular biology

Butler J, Kalogeropoulos A, Georgiopoulou V, de Rekeneire N, Rodondi N, Smith AL, Hoffmann U, Kanaya A, Newman AB, Kritchevsky SB, Vasan RS, Wilson PW, Harris TB

Risk factors for urinary incontinence among women with type 1 diabetes: findings from the epidemiology of diabetes interventions and complications study.

Urology

Sarma AV, Kanaya A, Nyberg LM, Kusek JW, Vittinghoff E, Rutledge B, Cleary PA, Gatcomb P, Brown JS

Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study.

Hypertension

Brinkley TE, Nicklas BJ, Kanaya AM, Satterfield S, Lakatta EG, Simonsick EM, Sutton-Tyrrell K, Kritchevsky SB

Total and regional adiposity and cognitive change in older adults: The Health, Aging and Body Composition (ABC) study.

Archives of neurology

Kanaya AM, Lindquist K, Harris TB, Launer L, Rosano C, Satterfield S, Yaffe K

Association between inflammatory components and physical function in the health, aging, and body composition study: a principal component analysis approach.

The journals of gerontology. Series A, Biological sciences and medical sciences

Hsu FC, Kritchevsky SB, Liu Y, Kanaya A, Newman AB, Perry SE, Visser M, Pahor M, Harris TB, Nicklas BJ

Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study.

Diabetologia

Poehls J, Wassel CL, Harris TB, Havel PJ, Swarbrick MM, Cummings SR, Newman AB, Satterfield S, Kanaya AM

Urinary incontinence among women with type 1 diabetes--how common is it?

The Journal of urology

Sarma AV, Kanaya AM, Nyberg LM, Kusek JW, Vittinghoff E, Rutledge B, Cleary PA, Gatcomb P, Brown JS

Restorative yoga in adults with metabolic syndrome: a randomized, controlled pilot trial.

Metabolic syndrome and related disorders

Cohen BE, Chang AA, Grady D, Kanaya AM

Fetuin-A and incident diabetes mellitus in older persons.

JAMA

Ix JH, Wassel CL, Kanaya AM, Vittinghoff E, Johnson KC, Koster A, Cauley JA, Harris TB, Cummings SR, Shlipak MG

Joint effects of adiposity and physical activity on incident mobility limitation in older adults.

Journal of the American Geriatrics Society

Koster A, Patel KV, Visser M, van Eijk JT, Kanaya AM, de Rekeneire N, Newman AB, Tylavsky FA, Kritchevsky SB, Harris TB

Relationship of ankle blood pressures to cardiovascular events in older adults.

Stroke; a journal of cerebral circulation

Sutton-Tyrrell K, Venkitachalam L, Kanaya AM, Boudreau R, Harris T, Thompson T, Mackey RH, Visser M, Vaidean GD, Newman AB

Body mass index and serum leptin concentration independently estimate percentage body fat in older adults.

The American journal of clinical nutrition

Ruhl CE, Harris TB, Ding J, Goodpaster BH, Kanaya AM, Kritchevsky SB, Simonsick EM, Tylavsky FA, Everhart JE

Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition study.

Human genetics

Wassel Fyr CL, Kanaya AM, Cummings SR, Reich D, Hsueh WC, Reiner AP, Harris TB, Moffett S, Li R, Ding J, Miljkovic-Gacic I, Ziv E

Endothelin-1 and prevalent coronary heart disease in older men and women (the Rancho Bernardo Study).

The American journal of cardiology

Kanaya AM, Barrett-Connor E, Wassel Fyr CL

Risk factors for mortality in middle-aged women.

Archives of internal medicine

Tice JA, Kanaya A, Hue T, Rubin S, Buist DS, Lacroix A, Lacey JV, Cauley JA, Litwack S, Brinton LA, Bauer DC

PPAR-gamma Pro12Ala genotype and risk of cognitive decline in elders.

Neurobiology of aging

Yaffe K, Kanaya AM, Lindquist K, Hsueh WC, Cummings SR, Beamer B, Newman A, Rosano C, Li R, Harris T

Quality-of-life impact and treatment of urinary incontinence in ethnically diverse older women.

Archives of internal medicine

Huang AJ, Brown JS, Kanaya AM, Creasman JM, Ragins AI, Van Den Eeden SK, Thom DH

How should developing countries manage diabetes?

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Narayan KM, Zhang P, Williams D, Engelgau M, Imperatore G, Kanaya A, Ramachandran A

Serum adiponectin and coronary heart disease risk in older Black and White Americans.

The Journal of clinical endocrinology and metabolism

Kanaya AM, Wassel Fyr C, Vittinghoff E, Havel PJ, Cesari M, Nicklas B, Harris T, Newman AB, Satterfield S, Cummings SR

Feasibility and acceptability of restorative yoga for treatment of hot flushes: a pilot trial.

Maturitas

Cohen BE, Kanaya AM, Macer JL, Shen H, Chang AA, Grady D

Impact of inflammation on the relationship among alcohol consumption, mortality, and cardiac events: the health, aging, and body composition study.

Archives of internal medicine

Maraldi C, Volpato S, Kritchevsky SB, Cesari M, Andresen E, Leeuwenburgh C, Harris TB, Newman AB, Kanaya A, Johnson KC, Rodondi N, Pahor M

Glycemia and cognitive function in older adults using glucose-lowering drugs.

The journal of nutrition, health & aging

Shorr RI, de Rekeneire N, Resnick HE, Yaffe K, Somes GW, Kanaya AM, Simonsick EM, Newman AB, Harris TB

Urinary incontinence and pelvic floor dysfunction in Asian-American women.

American journal of obstetrics and gynecology

Huang AJ, Thom DH, Kanaya AM, Wassel-Fyr CL, Van den Eeden SK, Ragins AI, Subak LL, Brown JS

Abdominal obesity is an independent risk factor for chronic heart failure in older people.

Journal of the American Geriatrics Society

Nicklas BJ, Cesari M, Penninx BW, Kritchevsky SB, Ding J, Newman A, Kitzman DW, Kanaya AM, Pahor M, Harris TB

Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1.

Archives of internal medicine

Kanaya AM, Wassel Fyr C, Vittinghoff E, Harris TB, Park SW, Goodpaster BH, Tylavsky F, Cummings SR

Lifestyle intervention is associated with lower prevalence of urinary incontinence: the Diabetes Prevention Program.

Diabetes care

Brown JS, Wing R, Barrett-Connor E, Nyberg LM, Kusek JW, Orchard TJ, Ma Y, Vittinghoff E, Kanaya AM

Preinfection systemic inflammatory markers and risk of hospitalization due to pneumonia.

American journal of respiratory and critical care medicine

Yende S, Tuomanen EI, Wunderink R, Kanaya A, Newman AB, Harris T, de Rekeneire N, Kritchevsky SB

Dietary glycemic index and load, measures of glucose metabolism, and body fat distribution in older adults.

The American journal of clinical nutrition

Sahyoun NR, Anderson AL, Kanaya AM, Koh-Banerjee P, Kritchevsky SB, de Rekeneire N, Tylavsky FA, Schwartz AV, Lee JS, Harris TB

Impaired fasting glucose and cardiovascular outcomes in postmenopausal women with coronary artery disease.

Annals of internal medicine

Kanaya AM, Herrington D, Vittinghoff E, Lin F, Bittner V, Cauley JA, Hulley S, Barrett-Connor E

Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule.

Diabetes care

Kanaya AM, Wassel Fyr CL, de Rekeneire N, Shorr RI, Schwartz AV, Goodpaster BH, Newman AB, Harris T, Barrett-Connor E

Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study.

Diabetologia

Snijder MB, Visser M, Dekker JM, Goodpaster BH, Harris TB, Kritchevsky SB, De Rekeneire N, Kanaya AM, Newman AB, Tylavsky FA, Seidell JC

The metabolic syndrome, inflammation, and risk of cognitive decline.

JAMA

Yaffe K, Kanaya A, Lindquist K, Simonsick EM, Harris T, Shorr RI, Tylavsky FA, Newman AB

Insulin-like growth factor-1.

Journal of the American Geriatrics Society

Colbert LH, Rosen CJ, Goodpaster BH, Newman AB, Kritchevsky SB, Satterfield S, Kanaya AM, Taaffe DR, Harris TB

Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study.

American journal of epidemiology

Nicklas BJ, Penninx BW, Cesari M, Kritchevsky SB, Newman AB, Kanaya AM, Pahor M, Jingzhong D, Harris TB

Serum leptin concentrations and body adipose measures in older black and white adults.

The American journal of clinical nutrition

Ruhl CE, Everhart JE, Ding J, Goodpaster BH, Kanaya AM, Simonsick EM, Tylavsky FA, Harris TB

Diabetes, impaired fasting glucose, and development of cognitive impairment in older women.

Neurology

Yaffe K, Blackwell T, Kanaya AM, Davidowitz N, Barrett-Connor E, Krueger K

Urinary incontinence in elderly women: findings from the Health, Aging, and Body Composition Study.

Obstetrics and gynecology

Jackson RA, Vittinghoff E, Kanaya AM, Miles TP, Resnick HE, Kritchevsky SB, Simonsick EM, Brown JS

Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults.

Diabetes care

Kanaya AM, Harris T, Goodpaster BH, Tylavsky F, Cummings SR

Association of total and central obesity with mortality in postmenopausal women with coronary heart disease.

American journal of epidemiology

Kanaya AM, Vittinghoff E, Shlipak MG, Resnick HE, Visser M, Grady D, Barrett-Connor E

Differences in medical care and disease outcomes among black and white women with heart disease.

Circulation

Jha AK, Varosy PD, Kanaya AM, Hunninghake DB, Hlatky MA, Waters DD, Furberg CD, Shlipak MG

Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial.

Annals of internal medicine

Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, Bittner V, Cauley JA, Barrett-Connor E

Association between thyroid dysfunction and total cholesterol level in an older biracial population: the health, aging and body composition study.

Archives of internal medicine

Kanaya AM, Harris F, Volpato S, Pérez-Stable EJ, Harris T, Bauer DC

Urinary tract infections in postmenopausal women: effect of hormone therapy and risk factors.

Obstetrics and gynecology

Brown JS, Vittinghoff E, Kanaya AM, Agarwal SK, Hulley S, Foxman B