Vanessa Jacoby, MD


Dr. Vanessa Jacoby is an obstetrician gynecologist with a research program focused on surgical gynecology. She has studied long-term health outcomes of hysterectomy and oophorectomy. She is the principal investigator of prospective cohort study of women with BRCA1 or BRCA2 mutations who undergo risk-reducing salpingo-oophorectomy funded by the American Cancer Society. Most recently, her research has focused on studies of new minimally invasive treatments for women with uterine fibroids. She is the principal investigator of a nationwide registry for women with fibroids undergoing laparoscopic radiofrequency ablation ( and has conducted multiple randomized trials of magnetic resonance guided focused ultrasound for fibroids. Dr. Jacoby is the principal investigator for the UCOP funded University of California Fibroid Network, a state-wide collaboration to improve the care of women with fibroids through research, education, and collaborative clinical practice. She is also the site principal investigator for the COMPARE-UF study (, a nationwide cohort study funded by PCORI to compare the effectiveness of surgical and medical fibroid treatments. Dr. Jacoby is also co-principal investigator of a PCORI Patient Powered Research Network (PPRN) called Community Engaged Network for All (CENA) that creates patient-centered disease registries.


The Comparing Options for Management: Patient-centered Results for Uterine Fibroids (COMPARE-UF) Registry: Rationale and Design.

American journal of obstetrics and gynecology

Stewart EA, Lytle BL, Thomas L, Wegienka GR, Jacoby V, Diamond MP, Nicholson WK, Anchan RM, Venable S, Wallace K, Marsh EE, Maxwell GL, Borah BJ, Catherino WH, Myers ER

Disparities in Fibroid Incidence, Prognosis, and Management.

Obstetrics and gynecology clinics of North America

Laughlin-Tommaso SK, Jacoby VL, Myers ER

Periprocedural outcomes comparing fibroid embolization and focused ultrasound: a randomized controlled trial and comprehensive cohort analysis.

American journal of obstetrics and gynecology

Barnard EP, AbdElmagied AM, Vaughan LE, Weaver AL, Laughlin-Tommaso SK, Hesley GK, Woodrum DA, Jacoby VL, Kohi MP, Price TM, Nieves A, Miller MJ, Borah BJ, Gorny KR, Leppert PC, Peterson LG, Stewart EA

Fibroid interventions: reducing symptoms today and tomorrow: extending generalizability by using a comprehensive cohort design with a randomized controlled trial.

American journal of obstetrics and gynecology

AbdElmagied AM, Vaughan LE, Weaver AL, Laughlin-Tommaso SK, Hesley GK, Woodrum DA, Jacoby VL, Kohi MP, Price TM, Nieves A, Miller MJ, Borah BJ, Gorny KR, Leppert PC, Lemens MA, Stewart EA

PROMISe trial: a pilot, randomized, placebo-controlled trial of magnetic resonance guided focused ultrasound for uterine fibroids.

Fertility and sterility

Jacoby VL, Kohi MP, Poder L, Jacoby A, Lager J, Schembri M, Rieke V, Grady D, Vittinghoff E, Coakley FV

Obstacles to Studying Emerging Technologies.

Obstetrics and gynecology

Waetjen LE, Parvataneni R, Varon S, Saberi NS, Jacoby VL

Managing symptoms and maximizing quality of life after preventive interventions for cancer risk reduction.

Current opinion in obstetrics & gynecology

Chapman JS, Jacoby V, Chen LM

Use of medical, surgical and complementary treatments among women with fibroids.

European journal of obstetrics, gynecology, and reproductive biology

Jacoby VL, Jacoby A, Learman LA, Schembri M, Gregorich SE, Jackson R, Kuppermann M

Screening pelvic examinations: right, wrong, or rite?

Annals of internal medicine

Sawaya GF, Jacoby V

Hysterectomy and urinary incontinence in postmenopausal women.

International urogynecology journal

Kudish BI, Shveiky D, Gutman RE, Jacoby V, Sokol AI, Rodabough R, Howard BV, Blanchette P, Iglesia CB

Hysterectomy controversies: ovarian and cervical preservation.

Clinical obstetrics and gynecology

Jacoby VL

Ovarian cancer rates after hysterectomy with and without salpingo-oophorectomy.

Obstetrics and gynecology

Chan JK, Urban R, Capra AM, Jacoby V, Osann K, Whittemore A, Habel LA

Risk-reducing salpingo-oophorectomy and ovarian cancer screening in 1077 women after BRCA testing.

JAMA internal medicine

Mannis GN, Fehniger JE, Creasman JS, Jacoby VL, Beattie MS

Reproductive and other health outcomes in Iraq and Afghanistan women veterans using VA health care: association with mental health diagnoses.

Women's health issues : official publication of the Jacobs Institute of Women's Health

Cohen BE, Maguen S, Bertenthal D, Shi Y, Jacoby V, Seal KH

Oophorectomy vs ovarian conservation with hysterectomy: cardiovascular disease, hip fracture, and cancer in the Women's Health Initiative Observational Study.

Archives of internal medicine

Jacoby VL, Grady D, Wactawski-Wende J, Manson JE, Allison MA, Kuppermann M, Sarto GE, Robbins J, Phillips L, Martin LW, O'Sullivan MJ, Jackson R, Rodabough RJ, Stefanick ML

Use of a ß-hCG discriminatory zone with bedside pelvic ultrasonography.

Annals of emergency medicine

Wang R, Reynolds TA, West HH, Ravikumar D, Martinez C, McAlpine I, Jacoby VL, Stein JC

Differential use of diagnostic ultrasound in u.s. Emergency departments by time of day.

The western journal of emergency medicine

Stein JC, Jacoby VL, Vittinghoff E, Wang R, Kwan E, Reynolds T, McAlpine I, Gonzales R

Emergency physician ultrasonography for evaluating patients at risk for ectopic pregnancy: a meta-analysis.

Annals of emergency medicine

Stein JC, Wang R, Adler N, Boscardin J, Jacoby VL, Won G, Goldstein R, Kohn MA

Racial and ethnic disparities in benign gynecologic conditions and associated surgeries.

American journal of obstetrics and gynecology

Jacoby VL, Fujimoto VY, Giudice LC, Kuppermann M, Washington AE

Health disparities: definitions and measurements.

American journal of obstetrics and gynecology

Dehlendorf C, Bryant AS, Huddleston HG, Jacoby VL, Fujimoto VY

Nationwide use of laparoscopic hysterectomy compared with abdominal and vaginal approaches.

Obstetrics and gynecology

Jacoby VL, Autry A, Jacobson G, Domush R, Nakagawa S, Jacoby A

Effect of bilateral oophorectomy on women's long-term health.

Women's health (London, England)

Parker WH, Jacoby V, Shoupe D, Rocca W

A survey of bedside ultrasound use by emergency physicians in California.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Stein JC, River G, Kalika I, Hebig A, Price D, Jacoby VL, Filly R

Factors associated with undergoing bilateral salpingo-oophorectomy at the time of hysterectomy for benign conditions.

Obstetrics and gynecology

Jacoby VL, Vittinghoff E, Nakagawa S, Jackson R, Richter HE, Chan J, Kuppermann M

Oophorectomy as a risk factor for coronary heart disease.

American journal of obstetrics and gynecology

Jacoby VL, Grady D, Sawaya GF

Persistent hot flushes in older postmenopausal women.

Archives of internal medicine

Huang AJ, Grady D, Jacoby VL, Blackwell TL, Bauer DC, Sawaya GF