Deborah Grady, MD, MPH is Professor of Medicine, Associate Dean for Clinical and Translational Research and Director of the UCSF Women's Health Clinical Research Center. Dr. Grady is an international expert on menopause and the risks and benefits of postmenopausal hormone therapy. Dr. Grady has trained and mentored over 40 young researchers interested in women's health and received the Chancellor's Award for the Advancement of Women and the UCSF Mentor of the Year award.

Postmenopausal Hormone Therapy

Postmenopausal hormone therapy is used by millions of women around the world. Hormone therapy is very effective for treatment of menopausal symptoms and affects the risk for several diseases including breast and uterine cancer, fractures, coronary disease, stroke, blood clots, dementia and diabetes. Dr. Grady has been a leader in studying these potential effects and helping clinicians and women weigh the risks and benefits.


About 2/3 of women suffer from hot flashes and other symptoms at menopause, and about 20% seek medical treatment. Postmenopausal hormone therapy is effective for treatment of hot flashes, but increases the risk of breast cancer, stroke, and dementia.

Dr. Grady is currently working with colleagues to:

  • Help understand the cause of hot flashes. The vasodilation and sweating that occur during a hot flash appear to occur because the brain senses that body temperature is too hot, even though the environment is not hot. Dr. Grady is working with physiologists interested in how the body controls heat to try to better understand how and why hot flashes occur.
  • Develop a miniature, wireless hot flash monitor. Researchers generally ask women to keep a diary of when hot flashes occur and to rate how severe they are. This is not a very good measurement, as it is difficult to keep a diary accurately, especially during sleep. To provide a more objective and accurate measure of the frequency of hot flashes and their severity, Dr. Grady is working with engineers to develop a miniature, wireless monitor that will automatically record hot flashes for up to 7 days.

    Develop and test treatments for hot flashes including:

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    Last Updated Friday June 01 2007